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A logger defends his family from a group of dangerous drug runners.

A quiet, stoic man, lives a monk-like existence in self-imposed exile. When his estranged son is killed in a drug deal gone bad, he is left to look after a granddaughter he never knew existed, and he is forced back into a life he tried to put behind him.

Construction company owner John Matthews learns that his estranged son, Jason, has been arrested for drug trafficking. Facing an unjust prison sentence for a first time offender courtesy of mandatory minimum sentence laws, Jason has nothing to offer for leniency in good conscience. Desperately, John convinces the DEA and the opportunistic DA Joanne Keeghan to let him go undercover to help make arrests big enough to free his son in return. With the unwitting help of an ex-con employee, John enters the narcotics underworld where every move could be his last in an operation that will demand all his resources, wits and courage to survive.

Three stories about the world of opioids collide: a drug trafficker arranges a multi-cartel Fentanyl smuggling operation between Canada and the U.S., an architect recovering from an OxyContin addiction tracks down the truth behind her son's involvement with narcotics, and a university professor battles unexpected revelations about his research employer, a drug company with deep government influence bringing a new "non-addictive" painkiller to market.

An American businessman with a stake in a pharmaceutical company that's about to go public finds his life is thrown into turmoil by an incident in Mexico.

Phil Broker, a retired DEA agent, leads a quiet life with his daughter Maddy, until a school bullying incident draws them into a conflict with Morgan “Gator” Bodine, a local crime boss.

A man vows to bring justice to those responsible for his wife's death while protecting the only family he has left, his daughter.

A boy named George Jung grows up in a struggling family in the 1950's. His mother nags at her husband as he is trying to make a living for the family. It is finally revealed that George's father cannot make a living and the family goes bankrupt. George does not want the same thing to happen to him, and his friend Tuna, in the 1960's, suggests that he deal marijuana. He is a big hit in California in the 1960's, yet he goes to jail, where he finds out about the wonders of cocaine. As a result, when released, he gets rich by bringing cocaine to America. However, he soon pays the price.