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All the couples are back for a wedding in Las Vegas, but plans for a romantic weekend go awry when their various misadventures get them into some compromising situations that threaten to derail the big event.

Aging pals Billy, Paddy, Archie, and Sam have been best friends since childhood. When Billy finally proposes to his much-younger girlfriend, all four friends go to Las Vegas to celebrate the end of Billy's longtime bachelorhood and relive their glory days. However, the four quickly realize that the intervening decades have changed Sin City and tested their friendship in ways they had not imagined.

Kyle Fisher has one last night to celebrate life as a single man before marrying Laura, so he sets out to Vegas with four of his best buddies. But a drug and alcohol filled night on the town with a stripper who goes all the way, turns into a cold night in the desert with shovels when the stripper goes all the way into a body bag after dying in their bathroom. And that's just the first of the bodies to pile up before Kyle can walk down the aisle...

Two best friends become rivals when their respective weddings are accidentally booked for the same day.

Carefree single guy Charlie Waters rooms with two lovely prostitutes, Barbara Miller and Susan Peters, and lives to gamble. Along with his glum betting buddy, Bill Denny, Charlie sets out on a gambling streak in search of the ever-elusive big payday. While Charlie and Bill have some lucky moments, they also have to contend with serious setbacks that threaten to derail their hedonistic betting binge.

Annie's life is a mess. But when she finds out her lifetime best friend is engaged, she simply must serve as Lillian's maid of honor. Though lovelorn and broke, Annie bluffs her way through the expensive and bizarre rituals. With one chance to get it perfect, she’ll show Lillian and her bridesmaids just how far you’ll go for someone you love.

Ben Sanderson, an alcoholic Hollywood screenwriter who lost everything because of his drinking, arrives in Las Vegas to drink himself to death. There, he meets and forms an uneasy friendship and non-interference pact with prostitute Sera.

When a straight-laced couple that has fun with a rowdy couple on vacation in Mexico return to the States, they discover that the crazy couple they met in Mexico followed them back home and decide to play tricks on them.